Disentangling capabilities for industry 4.0 - an information systems capability perspective

Digital technologies revolutionise the manufacturing industry by connecting the physical and digital worlds. The resulting paradigm shift, referred to as Industry 4.0, impacts manufacturing processes and business models. While the ‘why’ and ‘what’ of Industry 4.0 have been extensively researched, the ‘how’ remains poorly understood. Manufacturers struggle with exploiting Industry 4.0’s full potential as a holistic understanding of required Information Systems (IS) capabilities is missing. To foster such understanding, we present a holistic IS capability framework for Industry 4.0, including primary and support capabilities. After developing the framework based on a structured literature review, we refined and evaluated it with ten Industry 4.0 experts from research and practice. We demonstrated its use with a German machinery manufacturer. In sum, we contribute to understanding and analysing IS capabilities for Industry 4.0. Our work serves as a foundation for further theorising on Industry 4.0 and for deriving theory-led design recommendations for manufacturers

The Concept of a Smart Action – Results from Analyzing Information Systems Literature

In recent years, the term \u27smartness\u27 has entered widespread use in research and daily life. It has emerged with various applications of the Internet of Things, such as smart homes and smart factories. However, rapid technological development and careless use of the term mean that, in information systems (IS) research, a common understanding of smartness has not yet been established. And while it is recognized that smartness encompasses more than the use of impressive information technology applications, a unified conceptualization of how smartness is manifested in IS research is lacking. To this end, we conducted a structured literature review applying techniques from Grounded Theory. We found that smartness occurs through actions, in which smart things and individuals interact, process information, and make data-based decisions that are perceived as smart. Building on these findings, we propose the concept of a \u27smart action\u27 and derive a general definition of smartness. Our findings augment knowledge about how smartness is formed, offering a new perspective on smartness. The concept of a smart action unifies and increases understanding of \u27smartness\u27 in IS research. It supports further research by providing a concept for describing, analyzing, and designing smart actions, smart devices, and smart services

Structuring Digital Transformation: A Framework of Action Fields and its Application at ZEISS

Digital products and services are an integral part of everyday life for both individuals and organizations. Further, given that digitalization greatly impacts our society and in particular how customer and organizations interact, organizations need to react to changing business rules and to leverage opportunities associated with digital technologies. Accordingly, the chief information officer (CIO) role is frequently a flexible one in the sense that it encompasses a much broader perspective on organizations than before. Most of the CIOs or newly appointed chief digital officers (CDOs) whom we interviewed in the course of our study recognized the need for change catalyzed by emerging digital technologies, but they typically lacked comprehensive knowledge on how to scope digital transformation initiatives. Against this background, we develop and validate a holistic framework of action fields for digital transformation. Our framework builds on extant literature and a series of exploratory interviews with over 50 organizations, and we have validated it in numerous contexts. In this paper, we present our framework and demonstrate its application at ZEISS, one of the organizations that participated in our study

The European Respiratory Society and European Society of Thoracic Surgeons clinical guidelines for evaluating fitness for radical treatment (surgery and chemoradiotherapy) in patients with lung cancer

The European Respiratory Society (ERS) and the European Society of Thoracic Surgeons (ESTS) established a joint task force with the purpose to develop clinical evidence-based guidelines on evaluation of fitness for radical therapy in patients with lung cancer. The following topics were discussed, and are summarized in the final report along with graded recommendations: Cardiologic evaluation before lung resection; lung function tests and exercise tests (limitations of ppoFEV1; DLCO: systematic or selective?; split function studies; exercise tests: systematic; low-tech exercise tests; cardiopulmonary (high tech) exercise tests); future trends in preoperative work-up; physiotherapy/rehabilitation and smoking cessation; scoring systems; advanced care management (ICU/HDU); quality of life in patients submitted to radical treatment; combined cancer surgery and lung volume reduction surgery; compromised parenchymal sparing resections and minimally invasive techniques: the balance between oncological radicality and functional reserve; neoadjuvant chemotherapy and complications; definitive chemo and radiotherapy: functional selection criteria and definition of risk; should surgical criteria be re-calibrated for radiotherapy?; the patient at prohibitive surgical risk: alternatives to surgery; who should treat thoracic patients and where these patients should be treated

Extrinsic noise passing through a Michaelis-Menten reaction: A universal response of a genetic switch

The study of biochemical pathways usually focuses on a small section of a protein interactions network. Two distinct sources contribute to the noise in such a system: intrinsic noise, inherent in the studied reactions, and extrinsic noise generated in other parts of the network or in the environment. We study the effect of extrinsic noise entering the system through a nonlinear uptake reaction which acts as a nonlinear filter. Varying input noise intensity varies the mean of the noise after the passage through the filter, which changes the stability properties of the system. The steady-state displacement due to small noise is independent on the kinetics of the system but it only depends on the nonlinearity of the input function. For monotonically increasing and concave input functions such as the Michaelis-Menten uptake rate, we give a simple argument based on the small-noise expansion, which enables qualitative predictions of the steady-state displacement only by inspection of experimental data: when weak and rapid noise enters the system through a Michaelis-Menten reaction, then the graph of the system's steady states vs. the mean of the input signal always shifts to the right as noise intensity increases. We test the predictions on two models of lac operon, where TMG/lactose uptake is driven by a Michaelis-Menten enzymatic process. We show that as a consequence of the steady state displacement due to fluctuations in extracellular TMG/lactose concentration the lac switch responds in an asymmetric manner: as noise intensity increases, switching off lactose metabolism becomes easier and switching it on becomes more difficult.Comment: 25 pages, 9 figures, changed content, added figures, accepted for publication in Journal of Theoretical Biolog

Schwann cell hamartoma: case report

<p>Abstract</p> <p>Background</p> <p>Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening.</p> <p>Case presentation</p> <p>We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract.</p> <p>Conclusion</p> <p>As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.</p

Collins and Sivers asymmetries in muonproduction of pions and kaons off transversely polarised proton

Measurements of the Collins and Sivers asymmetries for charged pions and charged and neutral kaons produced in semi-inclusive deep-inelastic scattering of high energy muons off transversely polarised protons are presented. The results were obtained using all the available COMPASS proton data, which were taken in the years 2007 and 2010. The Collins asymmetries exhibit in the valence region a non-zero signal for pions and there are hints of non-zero signal also for kaons. The Sivers asymmetries are found to be positive for positive pions and kaons and compatible with zero otherwise.Comment: 15 pages, 13 figures and 1 tabl